Document Detail

Cell cycle arrest and cellular differentiation mediated by a cell surface sialoglycopeptide.
MedLine Citation:
PMID:  2041455     Owner:  NLM     Status:  MEDLINE    
Cell cycling by a relatively wide variety of cell lines was shown to be reversibly inhibited by a cell surface sialoglycopeptide (SGP) isolated and purified from intact bovine cerebral cortex cells. Cell cycle arrest, mediated by the bovine SGP inhibitor, was shown to be completely reversible with mouse Swiss 3T3, mouse 1316 fibrosarcoma, mouse N2a neuroblastoma, bovine MDBK and monkey BSC-1 cells. These cell lines represented both fibroblast and epithelial-like cells, transformed and nontransformed cells, as well as their being derived from a broad array of species. In contrast to the others tested, human HL-60 leukemic cells were sensitive to the inhibitory effects of the SGP but did not reenter the mitotic cycle after the removal of the inhibitor. Instead, the mitotic arrest of HL-60 cells appeared to enhance entry into a terminal and irreversible state of cellular differentiation.
G D Edson; H K Fattaey; T C Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  48     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1813-20     Citation Subset:  IM; S    
Center for Basic Center Research and BioServe Space Technologies, Kansas State University, Manhattan 66506.
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MeSH Terms
Cell Cycle / drug effects*
Cell Differentiation / drug effects
Cell Division / drug effects
Cell Line, Transformed
Epithelial Cells
Fibroblasts / cytology
Fibrosarcoma / pathology
Growth Inhibitors / pharmacology*
Leukemia, Experimental / pathology
Leukemia, Myeloid / pathology
Neuroblastoma / pathology
Sialoglycoproteins / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Growth Inhibitors; 0/Sialoglycoproteins; 0/sialoglycopeptide inhibitor protein, bovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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