| Cell cycle arrest and cellular differentiation mediated by a cell surface sialoglycopeptide. | |
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MedLine Citation:
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PMID: 2041455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell cycling by a relatively wide variety of cell lines was shown to be reversibly inhibited by a cell surface sialoglycopeptide (SGP) isolated and purified from intact bovine cerebral cortex cells. Cell cycle arrest, mediated by the bovine SGP inhibitor, was shown to be completely reversible with mouse Swiss 3T3, mouse 1316 fibrosarcoma, mouse N2a neuroblastoma, bovine MDBK and monkey BSC-1 cells. These cell lines represented both fibroblast and epithelial-like cells, transformed and nontransformed cells, as well as their being derived from a broad array of species. In contrast to the others tested, human HL-60 leukemic cells were sensitive to the inhibitory effects of the SGP but did not reenter the mitotic cycle after the removal of the inhibitor. Instead, the mitotic arrest of HL-60 cells appeared to enhance entry into a terminal and irreversible state of cellular differentiation. |
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Authors:
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G D Edson; H K Fattaey; T C Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 48 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-07-08 Completed Date: 1991-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1813-20 Citation Subset: IM; S |
Affiliation:
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Center for Basic Center Research and BioServe Space Technologies, Kansas State University, Manhattan 66506. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Cell Cycle / drug effects* Cell Differentiation / drug effects Cell Division / drug effects Cell Line, Transformed Epithelial Cells Fibroblasts / cytology Fibrosarcoma / pathology Growth Inhibitors / pharmacology* Humans Leukemia, Experimental / pathology Leukemia, Myeloid / pathology Mice Neuroblastoma / pathology Sialoglycoproteins / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 0/Sialoglycoproteins; 0/sialoglycopeptide inhibitor protein, bovine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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