| Cell cycle activation and CNS injury. | |
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MedLine Citation:
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PMID: 19526282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although traditionally it was believed that adult neurons have entered a permanent post-mitotic phase, the latest experimental data indicate that cell cycle constituents critically affect normal functions of the adult central nervous system (CNS), as well as contribute to the pathophysiology of both acute and chronic neurodegenerative disorders. Recent study has also suggested that cell cycle pathways are involved in mediating not only neuronal cell death but also glial changes which may play key roles in the pathophysiological mechanisms underlying acute and chronic neurodegenerative disorders. Therefore, therapies that inhibit cell cycle may have robust neuroprotective profiles, particularly after acute insults, by targeting multiple pathogenic mechanisms and could be useful clinically if used with a delivery focused on specific areas and of a limited duration. |
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Authors:
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Bogdan A Stoica; Kimberly R Byrnes; Alan I Faden |
Publication Detail:
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Type: Journal Article Date: 2009-04-21 |
Journal Detail:
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Title: Neurotoxicity research Volume: 16 ISSN: 1476-3524 ISO Abbreviation: Neurotox Res Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-17 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100929017 Medline TA: Neurotox Res Country: United States |
Other Details:
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Languages: eng Pagination: 221-37 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Georgetown University School of Medicine, Research Building, Room WG18, 3970 Reservoir Rd, NW, Washington, DC 20057, USA. stoicab@georgetown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Cell Cycle / physiology* Cell Death / physiology Central Nervous System / injuries*, metabolism, pathology*, physiopathology Cyclin-Dependent Kinases / metabolism DNA Damage Disease Models, Animal Humans Mice Models, Biological Neurodegenerative Diseases / metabolism, pathology*, physiopathology* Neuroglia / physiology Neurons / physiology Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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