Document Detail


Cell competition, growth and size control in the Drosophila wing imaginal disc.
MedLine Citation:
PMID:  19855017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report here experiments aimed at understanding the connections between cell competition and growth in the Drosophila wing disc. The principal assay has been to generate discs containing marked cells that proliferate at different rates and to study their interactions and their contribution to the final structure. It is known that single clones of fast-dividing cells within a compartment may occupy the larger part of the compartment without affecting its size. This has suggested the existence of interactions involving cell competition between fast- and slow-dividing cells directed to accommodate the contribution of each cell to the final compartment. Here we show that indeed fast-dividing cells can outcompete slow-dividing ones in their proximity. However, we argue that this elimination is of little consequence because preventing apoptosis, and therefore cell competition, in those compartments does not affect the size of the clones or the size of the compartments. Our experiments indicate that cells within a compartment proliferate autonomously at their own rate. The contribution of each cell to the compartment is exclusively determined by its division rate within the frame of a size control mechanism that stops growth once the compartment has reached the final arresting size. This is supported by a computer simulation of the contribution of individual fast clones growing within a population of slower dividing cells and without interacting with them. The values predicted by the simulation are very close to those obtained experimentally.
Authors:
Francisco A Martín; Salvador C Herrera; Ginés Morata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  136     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2009-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3747-56     Citation Subset:  IM    
Affiliation:
Centro de Biología Molecular CSIC-UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Drosophila / cytology,  growth & development*
Gene Expression Regulation, Developmental
Wing / growth & development*

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