Document Detail


Cell commitment and cell interactions in the ectoderm of Drosophila melanogaster.
MedLine Citation:
PMID:  1842356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The separation of neural from epidermal progenitor cells in the ventral neuroectoderm of Drosophila is thought to be mediated by cellular interactions. In order to verify the occurrence of regulatory signals and to test the neurogenic capabilities of cells from various regions of the ectoderm, we have carried out homotopic and heterotopic transplantations of single ectodermal cells. We found that cells from any of the tested regions, with the exception of the proctodeal anlage, are capable of developing as neuroblasts following their transplantation into the ventral neuroectoderm. These neurogenic capabilities are gradually distributed. Cells from the procephalic and ventral neurogenic regions exhibit maximal capabilities, as shown by their behavior in heterotopic transplantations. However, the two neurogenic regions differ from each other in that no epidermalising signals can be demonstrated to occur within the procephalic neuroectoderm, whereas such signals are strong within the ventral neuroectoderm; in addition, neuralising signals from neighbouring cells seem to be necessary for neuroectodermal cells to develop as neuroblasts. Other ectodermal regions whose cells exhibit weaker neurogenic capabilities are, in decreasing order of capability, the dorsal epidermal anlage, the anterolateral region of the procephalic lobe, comprising the anlage of the pharynx, and the anterior pole of the embryo, corresponding to the anlagen of the stomodeum and ectodermal anterior midgut. We assume that, during development in situ, the neurogenic capabilities of all these cells are suppressed by inhibitory signals, which are released upon heterotopic transplantation into the neuroectoderm. A community effect which prevents groups of dorsal epidermal cells from taking on a neural fate upon their transplantation into the ventral neuroectoderm, is shown.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
I Stüttem; J A Campos-Ortega
Related Documents :
6500176 - Stepwise commitment of blast cell fates during the positional specification of the o an...
17420246 - Nucleoplasmic calcium is required for cell proliferation.
20209436 - Ecdysone signaling is required for proper organization and fluid secretion of stellate ...
18456406 - Correlative analyses of notch signaling with resveratrol-induced differentiation and ap...
24321606 - An investigation of ultrasound effect on microalgal cell integrity and lipid extraction...
7522546 - Production of igf-i and igf binding proteins by retinal cells in vitro.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  Suppl 2     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1991  
Date Detail:
Created Date:  1993-01-04     Completed Date:  1993-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Affiliation:
Institut für Entwicklungsphysiologie, Universität zu Köln, FRG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Drosophila melanogaster / embryology*
Ectoderm / cytology*,  transplantation
Embryonic Induction / physiology
Microscopy, Fluorescence
Nervous System / cytology,  embryology*
Stem Cells / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cell lineage in the cerebral cortex.
Next Document:  Genetic control of primary neuronal development in zebrafish.