Document Detail

Cell commitment and cell interactions in the ectoderm of Drosophila melanogaster.
MedLine Citation:
PMID:  1842356     Owner:  NLM     Status:  MEDLINE    
The separation of neural from epidermal progenitor cells in the ventral neuroectoderm of Drosophila is thought to be mediated by cellular interactions. In order to verify the occurrence of regulatory signals and to test the neurogenic capabilities of cells from various regions of the ectoderm, we have carried out homotopic and heterotopic transplantations of single ectodermal cells. We found that cells from any of the tested regions, with the exception of the proctodeal anlage, are capable of developing as neuroblasts following their transplantation into the ventral neuroectoderm. These neurogenic capabilities are gradually distributed. Cells from the procephalic and ventral neurogenic regions exhibit maximal capabilities, as shown by their behavior in heterotopic transplantations. However, the two neurogenic regions differ from each other in that no epidermalising signals can be demonstrated to occur within the procephalic neuroectoderm, whereas such signals are strong within the ventral neuroectoderm; in addition, neuralising signals from neighbouring cells seem to be necessary for neuroectodermal cells to develop as neuroblasts. Other ectodermal regions whose cells exhibit weaker neurogenic capabilities are, in decreasing order of capability, the dorsal epidermal anlage, the anterolateral region of the procephalic lobe, comprising the anlage of the pharynx, and the anterior pole of the embryo, corresponding to the anlagen of the stomodeum and ectodermal anterior midgut. We assume that, during development in situ, the neurogenic capabilities of all these cells are suppressed by inhibitory signals, which are released upon heterotopic transplantation into the neuroectoderm. A community effect which prevents groups of dorsal epidermal cells from taking on a neural fate upon their transplantation into the ventral neuroectoderm, is shown.(ABSTRACT TRUNCATED AT 250 WORDS)
I Stüttem; J A Campos-Ortega
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  Suppl 2     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1991  
Date Detail:
Created Date:  1993-01-04     Completed Date:  1993-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Institut für Entwicklungsphysiologie, Universität zu Köln, FRG.
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MeSH Terms
Cell Differentiation / physiology*
Drosophila melanogaster / embryology*
Ectoderm / cytology*,  transplantation
Embryonic Induction / physiology
Microscopy, Fluorescence
Nervous System / cytology,  embryology*
Stem Cells / cytology*

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