Document Detail


Cell coat in tumor cells -- effects of trypsin and EDTA: a biochemical and morphological study.
MedLine Citation:
PMID:  185564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of trypsin and EDTA on the cell coat of ascites tumor cells were studied by means of biochemical and electron microscopy techniques. EDTA seems to release, by chelation of the Ca2+-bridges, an outer layer of glycoproteins of presumably exogenous origin. On the contrary, trypsin produces a deeper enzymic cleavage which appears to affect the structural integrity of the bilayered cell membrane. The significance of the cell leakage in tumor cells and the effect of EDTA on the modification of this leakage by change of cell membrane permeability are discussed.
Authors:
L J Anglhileri; Dermietzel
Related Documents :
303954 - Interactions of rodent malarial parasites with friend erythroleukemia cells in vitro.
11071364 - Long-term caffeine inhibits ehrlich ascites carcinoma cell-induced induction of central...
19055844 - Eradication of intractable malignant ascites by abdominocentesis, reinfusion of concent...
376724 - Immunoregulatory circuits among t cell sets: effect of mode of immunization on determin...
22980034 - The mechanics behind cell polarity.
12802064 - Receptor-mediated regulation of pi3ks confines pi(3,4,5)p3 to the leading edge of chemo...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology     Volume:  33     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Carcinoma, Ehrlich Tumor / metabolism,  ultrastructure*
Carcinoma, Hepatocellular / metabolism,  ultrastructure*
Cell Membrane / drug effects
Cell Membrane Permeability / drug effects
Edetic Acid / pharmacology*
Glycoproteins / metabolism
Glycosaminoglycans / metabolism
Liver Neoplasms
Membrane Lipids / metabolism
Membrane Proteins / metabolism
Mice
Microscopy, Electron
Neoplasms, Experimental / metabolism,  ultrastructure
Phospholipids / metabolism
Rats
Trypsin / pharmacology*
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Glycosaminoglycans; 0/Membrane Lipids; 0/Membrane Proteins; 0/Phospholipids; 60-00-4/Edetic Acid; 7440-70-2/Calcium; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prostaglandin regulation of adenylate kinases purifed from liver, skeletal muscle, and hepatoma.
Next Document:  Problems in polydactyly of the foot.