Document Detail

Cell coat in tumor cells -- effects of trypsin and EDTA: a biochemical and morphological study.
MedLine Citation:
PMID:  185564     Owner:  NLM     Status:  MEDLINE    
The effects of trypsin and EDTA on the cell coat of ascites tumor cells were studied by means of biochemical and electron microscopy techniques. EDTA seems to release, by chelation of the Ca2+-bridges, an outer layer of glycoproteins of presumably exogenous origin. On the contrary, trypsin produces a deeper enzymic cleavage which appears to affect the structural integrity of the bilayered cell membrane. The significance of the cell leakage in tumor cells and the effect of EDTA on the modification of this leakage by change of cell membrane permeability are discussed.
L J Anglhileri; Dermietzel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology     Volume:  33     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Carcinoma, Ehrlich Tumor / metabolism,  ultrastructure*
Carcinoma, Hepatocellular / metabolism,  ultrastructure*
Cell Membrane / drug effects
Cell Membrane Permeability / drug effects
Edetic Acid / pharmacology*
Glycoproteins / metabolism
Glycosaminoglycans / metabolism
Liver Neoplasms
Membrane Lipids / metabolism
Membrane Proteins / metabolism
Microscopy, Electron
Neoplasms, Experimental / metabolism,  ultrastructure
Phospholipids / metabolism
Trypsin / pharmacology*
Reg. No./Substance:
0/Glycoproteins; 0/Glycosaminoglycans; 0/Membrane Lipids; 0/Membrane Proteins; 0/Phospholipids; 60-00-4/Edetic Acid; 7440-70-2/Calcium; EC

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