| Cell "circadian" cycle: new role for mammalian core clock genes. | |
| | |
MedLine Citation:
|
PMID: 19221497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In mammals, 24 hours rhythms are organized as a biochemical network of molecular clocks that are operative in all tissues, with the master clock residing in the hypothalamic suprachiasmatic nucleus (SCN). The core pacemakers of these clocks consist of auto-regulatory transcriptional/post-transcriptional feedback loops. Several lines of evidence suggest the existence of a crosstalk between molecules that are responsible for the generation of circadian rhythms and molecules that control the cell cycle progression. In addition, highly specialized cell cycle checkpoints involved in DNA repair after damage seem also, at least in part, mediated by clock proteins. Recent studies have also highlighted a putative connection between clock protein dysfunction and cancer progression. This review discusses the intimate relation that exists between cell cycle progression and components of the circadian machinery. |
| | |
Authors:
|
Laurence Borgs; Pierre Beukelaers; Renaud Vandenbosch; Shibeshih Belachew; Laurent Nguyen; Brigitte Malgrange |
Related Documents
:
|
22311767 - Proteomic profiling of the epithelial-mesenchymal transition using 2d dige. 3875577 - Recruitment of cells in the small intestine into rapid cell cycle by small doses of ext... 10074167 - Expression of ebna-1 mrna is regulated by cell cycle during epstein-barr virus type i l... 20517887 - Functional roles of pc-plc and cdc20 in the cell cycle, proliferation, and apoptosis. 8206447 - Established cell lines for safety assessment of food contaminants: differing furazolido... 21548757 - Proton mr spectroscopy of neural stem cells: does the proton-nmr peak at 1.28 ppm fun... |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-03-16 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 8 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2009 Mar |
Date Detail:
|
Created Date: 2009-03-16 Completed Date: 2009-05-08 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 832-7 Citation Subset: IM |
Affiliation:
|
Developmental Neurobiology Unit, Center for Cellular and Molecular Neurobiology, University of Liège, Liège, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Clocks / genetics, physiology* CLOCK Proteins Cell Cycle / genetics, physiology* Cell Cycle Proteins / genetics, metabolism* Circadian Rhythm / genetics, physiology* DNA Damage / genetics, physiology Humans Signal Transduction / genetics, physiology Trans-Activators / genetics, metabolism* Transcription Factors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Cell Cycle Proteins; 0/Trans-Activators; 0/Transcription Factors; EC 2.3.1.48/CLOCK Proteins; EC 2.3.1.48/CLOCK protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: One renegade cancer stem cell?
Next Document: Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitr...