| Cell cholesterol homeostasis: mediation by active cholesterol. | |
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MedLine Citation:
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PMID: 20843692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence suggests that the major pathways mediating cell cholesterol homeostasis respond to a common signal: active membrane cholesterol. Active cholesterol is the fraction that exceeds the complexing capacity of the polar bilayer lipids. Increments in plasma membrane cholesterol exceeding this threshold have an elevated chemical activity (escape tendency) and redistribute via diverse transport proteins to both circulating plasma lipoproteins and intracellular organelles. Active cholesterol thereby prompts several feedback responses. It is the substrate for its own esterification and for the synthesis of regulatory side-chain oxysterols. It also stimulates manifold pathways that down-regulate the biosynthesis, curtail the ingestion and increase the export of cholesterol. Thus, the abundance of cell cholesterol is tightly coupled to that of its polar lipid partners through active cholesterol. |
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Authors:
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Theodore L Steck; Yvonne Lange |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-09-16 |
Journal Detail:
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Title: Trends in cell biology Volume: 20 ISSN: 1879-3088 ISO Abbreviation: Trends Cell Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-22 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 680-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. tsteck@bsd.uchicago.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / metabolism Cholesterol / metabolism* Fatty Acid-Binding Proteins / metabolism Homeostasis Humans Intracellular Membranes / metabolism Organelles / metabolism Phospholipids / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL 28448/HL/NHLBI NIH HHS; R01 HL028448-21A1/HL/NHLBI NIH HHS; R01 HL028448-25A1/HL/NHLBI NIH HHS; R01 HL028448-27/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acid-Binding Proteins; 0/Phospholipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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