Document Detail

Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins.
MedLine Citation:
PMID:  8910001     Owner:  NLM     Status:  MEDLINE    
Intratumoral phenotypic diversity is well documented with regard to tumor associated carbohydrate antigens (TACA). The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at different surface densities (number of cells per cm2 of growth flask). Results show that the apparent expression of extended Lea-Lex, Lea and Lex, sialyl Lea, Tn and sialyl Tn varies with density of growth by an invasive human squamous cell lung carcinoma cell line (NU6-1), a benign variant (NE-18) and the human lung epithelial cell line BEAS-2B. The results indicate that one of the factors influencing the apparent expression of mucin-associated oligosaccharides is cell-cell interactions.
P L Stranahan; J Laroe; R McCombs; A Goldsmith; I Rahim; M Overland; D E Pettijohn
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Glycoconjugate journal     Volume:  13     ISSN:  0282-0080     ISO Abbreviation:  Glycoconj. J.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8603310     Medline TA:  Glycoconj J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  741-7     Citation Subset:  IM    
University of Colorado Cancer Center, Denver 80262, USA.
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MeSH Terms
Antibodies, Monoclonal / immunology,  metabolism
Antigens, Tumor-Associated, Carbohydrate / immunology,  metabolism
Cell Division
Clone Cells
Epitopes / chemistry,  genetics
Gene Expression Regulation, Neoplastic / genetics
Lewis Blood-Group System / analysis,  metabolism
Lung Neoplasms / metabolism
Membrane Glycoproteins / metabolism*
Microscopy, Phase-Contrast
Mucins / immunology,  metabolism*
Oligosaccharides / chemistry,  metabolism
Tumor Cells, Cultured
Grant Support
71109-500802//PHS HHS; P50 CA58187/CA/NCI NIH HHS; R25 CA49981/CA/NCI NIH HHS
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Epitopes; 0/Lewis Blood-Group System; 0/Membrane Glycoproteins; 0/Mucins; 0/Oligosaccharides

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