Document Detail


Cell-cell interactions in the osteogenic compartment of bone.
MedLine Citation:
PMID:  3408595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interactions between two different cell populations within the osteogenic compartment have been examined. The proliferation of periosteal fibroblasts (PF) in the presence or absence of osteoblast-like cells (OB), whose proliferative capacity was inhibited by irradiation, was measured. OB stimulated [3H]thymidine incorporation in PF and parathyroid hormone (PTH) enhanced the stimulation. In the reverse situation, however, PF inhibited OB. Irradiated OB also stimulated 3H-thymidine incorporation in OB, and irradiated PF in PF, but both to a lesser extent. Co-culture experiments showed that direct cell-cell contact was a prerequisite for stimulation of PF. Medium mediated contact between physically separated OB and PF did not stimulate, but rather inhibited PF proliferation. These results demonstrate that OB regulate the proliferation of cells in the PF population and can transmit the proliferation stimulating message of PTH to PF. This implies that in vivo the mature osteoblast may play a pivotal role in the (hormonal) regulation of osteoprogenitor cell proliferation and therefore bone formation.
Authors:
A van der Plas; P J Nijweide
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone     Volume:  9     ISSN:  8756-3282     ISO Abbreviation:  Bone     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-04     Completed Date:  1988-10-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM; S    
Affiliation:
Laboratory of Cell Biology and Histology, University of Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication*
Cell Division
Cells, Cultured
Chick Embryo
DNA / biosynthesis
Fibroblasts / cytology,  metabolism,  physiology
Osteoblasts / physiology*,  radiation effects
Osteogenesis*
Periosteum / cytology,  metabolism,  physiology*
Thymidine / metabolism
Chemical
Reg. No./Substance:
50-89-5/Thymidine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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