Document Detail

Cell-cell interaction and carcinogenesis.
MedLine Citation:
PMID:  3538348     Owner:  NLM     Status:  MEDLINE    
Before carcinogenic stimuli are introduced, a potentially cancerous cell functions normally; growth is controlled and the cell exists in complete harmony with that of surrounding cells in a given tissue. During the process of multi-stage carcinogenesis, such harmony is destroyed and a presumptive initiated cell accomplishes a clonal expansion, neglecting the growth pattern of surrounding normal cells. Recent results from our own laboratory and others strongly suggest that blocked gap-junctional intercellular communication is an important determinant during the process of tumor promotion.
H Yamasaki
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Toxicologic pathology     Volume:  14     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-21     Completed Date:  1987-01-21     Revised Date:  2009-07-01    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
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MeSH Terms
Binding Sites
Carcinogens / toxicity
Cell Communication* / drug effects
Cell Transformation, Neoplastic*
Cells, Cultured
Intercellular Junctions / drug effects,  physiology
Phorbol Esters / metabolism,  toxicity
Protein Kinase C / metabolism
Grant Support
1 R01 CA40534-01/CA/NCI NIH HHS
Reg. No./Substance:
0/Carcinogens; 0/Phorbol Esters; EC Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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