| Cell-cell interaction and carcinogenesis. | |
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MedLine Citation:
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PMID: 3538348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Before carcinogenic stimuli are introduced, a potentially cancerous cell functions normally; growth is controlled and the cell exists in complete harmony with that of surrounding cells in a given tissue. During the process of multi-stage carcinogenesis, such harmony is destroyed and a presumptive initiated cell accomplishes a clonal expansion, neglecting the growth pattern of surrounding normal cells. Recent results from our own laboratory and others strongly suggest that blocked gap-junctional intercellular communication is an important determinant during the process of tumor promotion. |
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Authors:
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H Yamasaki |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Toxicologic pathology Volume: 14 ISSN: 0192-6233 ISO Abbreviation: Toxicol Pathol Publication Date: 1986 |
Date Detail:
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Created Date: 1987-01-21 Completed Date: 1987-01-21 Revised Date: 2009-07-01 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 363-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding Sites Carcinogens / toxicity Cell Communication* / drug effects Cell Transformation, Neoplastic* Cells, Cultured Humans Intercellular Junctions / drug effects, physiology Phorbol Esters / metabolism, toxicity Protein Kinase C / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 CA40534-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Phorbol Esters; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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