Document Detail

Cell-cell fusion.
MedLine Citation:
PMID:  17395182     Owner:  NLM     Status:  MEDLINE    
Cell-cell fusion is a highly regulated and dramatic cellular event that is required for development and homeostasis. Fusion may also play a role in the development of cancer and in tissue repair by stem cells. While virus-cell fusion and the fusion of intracellular membranes have been the subject of intense investigation during the past decade, cell-cell fusion remains poorly understood. Given the importance of this cell-biological phenomenon, a number of investigators have begun analyses of the molecular mechanisms that mediate the specialized fusion events of a variety of cell types and species. We discuss recent genetic and biochemical studies that are beginning to yield exciting insights into the fusion mechanisms of Saccharomyces cerevisiae mating pairs, Caenorhabditis elegans epithelial cells and gametes, Drosophila melanogaster and mammalian myoblasts, and mammalian macrophages.
Elizabeth H Chen; Eric Grote; William Mohler; Agnès Vignery
Publication Detail:
Type:  Journal Article; Review     Date:  2007-03-21
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2181-93     Citation Subset:  IM    
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
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MeSH Terms
Caenorhabditis elegans / cytology,  physiology
Cell Fusion*
Macrophages / cytology,  physiology
Membrane Fusion / physiology*
Myoblasts / cytology,  physiology
Saccharomyces cerevisiae / cytology,  physiology

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