Document Detail


Cell and cell-free transplantation experiments with a mouse reticulum cell sarcoma.
MedLine Citation:
PMID:  7018039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative cellular assays of the transplantability of 19 spontaneous reticulum cell sarcomas (RCS) of the BC3F1 mouse were carried out by injecting serial dilutions of monodispersed cells into syngeneic hosts through the intravenous, intracranial and subcutaneous routes. A clear relationship was found between the size of the inoculum and the incidence of tumour takes by all routes, but even for inocula of 5 million cells only 13 tumors grew in one or more of the transplanted recipients. The intravenous route of injection was found to be the most effective, both in terms of the absolute number of tumor takes and the number of cells necessary to produce a given level of takes. The survival of the animals injected intravenously was related to the number of cells received in that earlier deaths occurred with the most concentrated cell suspensions. Attempts to transmit the tumor by cell-free extracts injected into newborn or 1-month-old syngeneic hosts failed to substantiate the possible presence of a specific leukemogenic agent.
Authors:
V Covelli; V Di Majo; B Bassani; P Metalli; G Silini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  67     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell-Free System
Female
Lymphoma, Non-Hodgkin / pathology*
Male
Mice
Neoplasm Transplantation* / methods
Sarcoma, Experimental / pathology
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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