Document Detail

Cell-cell communication in the pituitary: orchestrator of pulsatile growth hormone secretion?
MedLine Citation:
PMID:  16938459     Owner:  NLM     Status:  MEDLINE    
Hormone secretion is dependent on intracellular and extracellular regulation of hormone synthesis and release, including classical endocrine and paracrine mechanisms and transcription factors that determine cell differentiation and hormone gene transcription. Recent research has identified direct cell-cell communication in a three-dimensional network of pituitary growth hormone-secreting cells connected by adherens junctions. This challenges the conventional view of endocrine cells as collections of dispersed cells and suggests that physical connectivity mediates cellular responses to coordinate pulsatile secretion.
Sylvia L Asa; Gloria S Tannenbaum
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-08-30
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  17     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-300     Citation Subset:  IM    
Department of Laboratory Medicine and Pathobiology, University of Toronto and Department of Pathology, University Health Network and Toronto Medical Laboratories, Toronto, Ontario M5G 2C4, Canada.
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MeSH Terms
Cell Communication / physiology
Growth Hormone / biosynthesis,  secretion*
Pituitary Gland / physiology,  secretion*
Pulsatile Flow / physiology
Somatotrophs / secretion
Reg. No./Substance:
9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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