Document Detail

Cell bioprocessing in space: applications of analytical cytology.
MedLine Citation:
PMID:  11538247     Owner:  NASA     Status:  MEDLINE    
Cell bioprocessing in space consists of the preparation, cultivation, purification and investigation of cells and their products in the microgravity environment of orbital space flight. Inertial acceleration is used as an independent variable to explore the limits of specific bioprocessing functions, such as cell growth and secretion, gravity-dependent phenomena in cell bioreactors, cell fusion, the influence of thermal convection on processes at cellular dimensions, the electrophoretic separation of cell subpopulations and subcellular particles, and two-phase partitioning of cells, bioparticles, and macromolecules. Analytical cytology techniques are under development for on-orbit application to future cell growth and separation experiments, such as those anticipated in the Space Station era.
P Todd; W C Hymer; D R Morrison; C L Goolsby; J M Hatfield; M E Kunze; K Motter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  The Physiologist     Volume:  31     ISSN:  0031-9376     ISO Abbreviation:  Physiologist     Publication Date:  1988  
Date Detail:
Created Date:  1997-10-10     Completed Date:  1997-10-10     Revised Date:  2007-07-17    
Medline Journal Info:
Nlm Unique ID:  0401143     Medline TA:  Physiologist     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S52-5     Citation Subset:  S    
Althouse Laboratory, The Pennsylvania State University, University Park 16802, USA.
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MeSH Terms
Cell Division / physiology
Cell Separation / methods*
Cells, Cultured
Cytological Techniques / instrumentation
Flow Cytometry / instrumentation,  methods*
Space Flight / instrumentation*
Spacecraft / instrumentation
P Todd / Bioproc & Pharm Res Ctr, Philadelphia, PA; W C Hymer / PA St U, University Park, Dept Mol & Cell Biol; D R Morrison / JSC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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