| Cell bioprocessing in space: applications of analytical cytology. | |
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MedLine Citation:
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PMID: 11538247 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Cell bioprocessing in space consists of the preparation, cultivation, purification and investigation of cells and their products in the microgravity environment of orbital space flight. Inertial acceleration is used as an independent variable to explore the limits of specific bioprocessing functions, such as cell growth and secretion, gravity-dependent phenomena in cell bioreactors, cell fusion, the influence of thermal convection on processes at cellular dimensions, the electrophoretic separation of cell subpopulations and subcellular particles, and two-phase partitioning of cells, bioparticles, and macromolecules. Analytical cytology techniques are under development for on-orbit application to future cell growth and separation experiments, such as those anticipated in the Space Station era. |
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Authors:
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P Todd; W C Hymer; D R Morrison; C L Goolsby; J M Hatfield; M E Kunze; K Motter |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: The Physiologist Volume: 31 ISSN: 0031-9376 ISO Abbreviation: Physiologist Publication Date: 1988 |
Date Detail:
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Created Date: 1997-10-10 Completed Date: 1997-10-10 Revised Date: 2007-07-17 |
Medline Journal Info:
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Nlm Unique ID: 0401143 Medline TA: Physiologist Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S52-5 Citation Subset: S |
Affiliation:
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Althouse Laboratory, The Pennsylvania State University, University Park 16802, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acceleration Animals Biotechnology Cell Division / physiology Cell Separation / methods* Cells, Cultured Cytological Techniques / instrumentation Dogs Flow Cytometry / instrumentation, methods* Humans Rats Space Flight / instrumentation* Spacecraft / instrumentation Weightlessness* |
| Investigator | |
Investigator/Affiliation:
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P Todd / Bioproc & Pharm Res Ctr, Philadelphia, PA; W C Hymer / PA St U, University Park, Dept Mol & Cell Biol; D R Morrison / JSC |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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