Document Detail


Cell bioprocessing in space: applications of analytical cytology.
MedLine Citation:
PMID:  11538247     Owner:  NASA     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell bioprocessing in space consists of the preparation, cultivation, purification and investigation of cells and their products in the microgravity environment of orbital space flight. Inertial acceleration is used as an independent variable to explore the limits of specific bioprocessing functions, such as cell growth and secretion, gravity-dependent phenomena in cell bioreactors, cell fusion, the influence of thermal convection on processes at cellular dimensions, the electrophoretic separation of cell subpopulations and subcellular particles, and two-phase partitioning of cells, bioparticles, and macromolecules. Analytical cytology techniques are under development for on-orbit application to future cell growth and separation experiments, such as those anticipated in the Space Station era.
Authors:
P Todd; W C Hymer; D R Morrison; C L Goolsby; J M Hatfield; M E Kunze; K Motter
Related Documents :
10197607 - Differential transactivation by alternative ews-fli1 fusion proteins correlates with cl...
20309577 - Generation of highly pure fusions of colorectal carcinoma and antigen-presenting cells.
18616937 - Founder cells regulate fiber number but not fiber formation during adult myogenesis in ...
200587 - Human cytomegalovirions and dense bodies: glycopeptide analysis and mechanism of cell r...
12893307 - Electrochemical study of heavy metals and metallothionein in yeast yarrowia lipolytica.
8679107 - Polylysine enhances cationic liposome-mediated transfection of the hepatoblastoma cell ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  The Physiologist     Volume:  31     ISSN:  0031-9376     ISO Abbreviation:  Physiologist     Publication Date:  1988  
Date Detail:
Created Date:  1997-10-10     Completed Date:  1997-10-10     Revised Date:  2007-07-17    
Medline Journal Info:
Nlm Unique ID:  0401143     Medline TA:  Physiologist     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S52-5     Citation Subset:  S    
Affiliation:
Althouse Laboratory, The Pennsylvania State University, University Park 16802, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acceleration
Animals
Biotechnology
Cell Division / physiology
Cell Separation / methods*
Cells, Cultured
Cytological Techniques / instrumentation
Dogs
Flow Cytometry / instrumentation,  methods*
Humans
Rats
Space Flight / instrumentation*
Spacecraft / instrumentation
Weightlessness*
Investigator
Investigator/Affiliation:
P Todd / Bioproc & Pharm Res Ctr, Philadelphia, PA; W C Hymer / PA St U, University Park, Dept Mol & Cell Biol; D R Morrison / JSC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Does vector-free gravity simulate microgravity? Functional and morphologic attributes of clinorotat...
Next Document:  Adaptation to restraint in the rat.