| Cell biology of cardiac mitochondrial phospholipids. | |
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MedLine Citation:
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PMID: 15052331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phospholipids are important structural and functional components of all biological membranes and define the compartmentation of organelles. Mitochondrial phospholipids comprise a significant proportion of the entire phospholipid content of most eukaroytic cells. In the heart, a tissue rich in mitochondria, the mitochondrial phospholipids provide for diverse roles in the regulation of various mitochondrial processes including apoptosis, electron transport, and mitochondrial lipid and protein import. It is well documented that alteration in the content and fatty acid composition of phospholipids within the heart is linked to alterations in myocardial electrical activity. In addition, reduction in the specific mitochondrial phospholipid cardiolipin is an underlying biochemical cause of Barth Syndrome, a rare and often fatal X-linked genetic disease that is associated with cardiomyopathy. Thus, maintenance of both the content and molecular composition of phospholipids synthesized within the mitochondria is essential for normal cardiac function. This review will focus on the function and regulation of the biosynthesis and resynthesis of mitochondrial phospholipids in the mammalian heart. |
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Authors:
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Grant M Hatch |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemistry and cell biology = Biochimie et biologie cellulaire Volume: 82 ISSN: 0829-8211 ISO Abbreviation: Biochem. Cell Biol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-03-30 Completed Date: 2004-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8606068 Medline TA: Biochem Cell Biol Country: Canada |
Other Details:
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Languages: eng Pagination: 99-112 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada. hatchgm@ms.umanitoba.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiolipins / metabolism Humans Mitochondria, Heart / metabolism* Phosphatidylethanolamines / metabolism Phosphatidylglycerols / metabolism Phospholipids / biosynthesis*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Phosphatidylethanolamines; 0/Phosphatidylglycerols; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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