Document Detail


Cell biologic properties in explant culture and heterotransplantation of malignant uterine cervical cells.
MedLine Citation:
PMID:  3425154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell of origin of uterine cervical cancer was studied by using culture, enzyme histochemistry and heterotransplantation. Twenty-seven epidermoid carcinomas (8 large cell keratinizing squamous, 12 large cell nonkeratinizing squamous and 7 small cell nonkeratinizing squamous) and 2 adenocarcinomas of the uterine cervix were placed in culture. An outgrowth of carcinoma cells in vitro was observed in 22 of 29 cases: 6 keratinizing, 8 large cell nonkeratinizing and 6 small cell nonkeratinizing carcinomas and 2 adenocarcinomas. The squamous carcinomas showed a squamous-cell outgrowth pattern, except for one large cell nonkeratinizing and three small cell nonkeratinizing carcinomas that showed a glandular-cell outgrowth pattern. One of three keratinizing carcinomas was transplantable into the subcutis of BALB/c nude mice, producing keratinizing tumors; three of six large cell and one of three small cell nonkeratinizing carcinomas reproduced themselves, while the other two small cell carcinomas produced poorly differentiated adenocarcinomas in mice. The transplanted adenocarcinoma produced a well-differentiated adenocarcinoma resembling the original tumor. Small cell carcinomas and adenocarcinomas contained a heat-stable, L-phenylalanine-sensitive alkaline phosphatase. These results suggest that many uterine cervical cancers originate from the reserve cell.
Authors:
I Ishiwata; C Ishiwata; M Soma; S Nozawa; H Ishikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cytologica     Volume:  31     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1987 Nov-Dec
Date Detail:
Created Date:  1988-01-25     Completed Date:  1988-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-34     Citation Subset:  IM    
Affiliation:
Ishiwata Obstetrical and Gynecological Hospital, Mito, Japan.
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MeSH Terms
Descriptor/Qualifier:
Alkaline Phosphatase / metabolism
Cell Division
Chromosome Mapping
Female
Humans
Neoplasm Transplantation*
Transplantation, Heterologous
Tumor Cells, Cultured
Uterine Cervical Neoplasms / enzymology,  genetics,  pathology*
Chemical
Reg. No./Substance:
EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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