| Cell-based vasculogenic studies in preclinical models of chronic myocardial ischaemia and hibernation. | |
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MedLine Citation:
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PMID: 23256710 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Coronary artery disease commonly leads to myocardial ischaemia and hibernation. Relevant preclinical models of these conditions are essential to evaluate new therapeutic options such as cell-based vasculogenic therapies. Areas covered: In this article, the authors first review basic concepts of myocardial ischaemia/hibernation and relevant techniques to assess myocardial viability. Then, preclinical models of chronic myocardial ischaemia and hibernation, induced by devices such as ameroid constrictors, Delrin stenosis, hydraulic occluders, and coils/stents are described. Lastly, the authors discuss cell-based vasculogenic therapy, and summarise studies conducted in large animal models of chronic myocardial ischaemia and hibernation. Expert opinion: Approximately one-third of patients with viable myocardium do not undergo revascularisation; however, this population is at high risk for cardiac events and would surely benefit from effective cell-based therapy. Because of the modest benefits in clinical studies, preclinical models accurately representing clinical myocardial ischemia/hibernation are necessary to better understand and appropriately direct regenerative therapy research. |
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Authors:
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Céline Giordano; Drew Kuraitis; Rob Sb Beanlands; Erik J Suuronen; Marc Ruel |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: - ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Ottawa Heart Institute, Division of Cardiac Surgery , 40 Ruskin Street, Suite 3403, Ottawa, Ontario, K1Y 4W7 , Canada +1613 761 4893 ; +1613 761 5367 ; mruel@ottawaheart.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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