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Cell-based therapies for Parkinson's disease.
MedLine Citation:
PMID:  21651331     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, classically characterized by a triad of motor features: bradykinesia, rigidity and resting tremor. Neurodegeneration in PD critically involves the dopaminergic neurons of the substantia nigra pars compacta, which results in a severe reduction in dopamine levels in the dorsal striatum. However, the disease also exhibits extensive non-nigral pathology and as many non-motor as motor features. Nevertheless, owing to the relatively circumscribed nature of the nigrostriatal lesion in PD, dopaminergic cell transplantation has emerged as a potentially reparative therapy for the disease. Sources for such cells are varied and include the developing ventral mesencephalon, several autologous somatic cell types, embryonic stem cells and induced pluripotent stem cells. In this article, we review the origins of dopaminergic transplantation for PD and the emergent hunt for a suitable long-term source of transplantable dopaminergic neurons.
Authors:
Sean C Dyson; Roger A Barker
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  11     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  831-44     Citation Subset:  IM    
Affiliation:
Cambridge University Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK.
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