Document Detail


Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.
MedLine Citation:
PMID:  20116850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation and osteoclast activating factors without obvious effect on cell viability. Steroid compounds specifically decreased angiogenesis-related factors, but stimulated osteoclast activating factors. Antihelmintic drugs potently inhibited cytokines and were cytotoxic. The screen identified potential candidates with potent anti-MM properties that need further investigation.
Authors:
Rentian Feng; Jorge A Rios; Tomifumi Onishi; Anna Lokshin; Elieser Gorelik; Suzanne Lentzsch
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-08
Journal Detail:
Title:  Leukemia research     Volume:  34     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  917-24     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / pharmacology
Anthelmintics / pharmacology
Anti-Infective Agents / pharmacology
Antineoplastic Agents / isolation & purification,  pharmacology*
Apoptosis / drug effects
B-Lymphocytes / drug effects,  secretion
Bone Marrow Cells / cytology,  drug effects
Cardiac Glycosides / pharmacology
Cell Differentiation / drug effects
Cell Line, Tumor / drug effects,  secretion
Cytokines / antagonists & inhibitors*,  secretion
Drug Screening Assays, Antitumor / methods*
Growth Inhibitors / isolation & purification,  pharmacology*
High-Throughput Screening Assays / methods*
Humans
Immunoassay / methods*
Microspheres
Multiple Myeloma / drug therapy*
Osteoclasts / cytology
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anthelmintics; 0/Anti-Infective Agents; 0/Antineoplastic Agents; 0/Cardiac Glycosides; 0/Cytokines; 0/Growth Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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