| Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. | |
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MedLine Citation:
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PMID: 20116850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation and osteoclast activating factors without obvious effect on cell viability. Steroid compounds specifically decreased angiogenesis-related factors, but stimulated osteoclast activating factors. Antihelmintic drugs potently inhibited cytokines and were cytotoxic. The screen identified potential candidates with potent anti-MM properties that need further investigation. |
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Authors:
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Rentian Feng; Jorge A Rios; Tomifumi Onishi; Anna Lokshin; Elieser Gorelik; Suzanne Lentzsch |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-08 |
Journal Detail:
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Title: Leukemia research Volume: 34 ISSN: 1873-5835 ISO Abbreviation: Leuk. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 917-24 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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pharmacology Anthelmintics / pharmacology Anti-Infective Agents / pharmacology Antineoplastic Agents / isolation & purification, pharmacology* Apoptosis / drug effects B-Lymphocytes / drug effects, secretion Bone Marrow Cells / cytology, drug effects Cardiac Glycosides / pharmacology Cell Differentiation / drug effects Cell Line, Tumor / drug effects, secretion Cytokines / antagonists & inhibitors*, secretion Drug Screening Assays, Antitumor / methods* Growth Inhibitors / isolation & purification, pharmacology* High-Throughput Screening Assays / methods* Humans Immunoassay / methods* Microspheres Multiple Myeloma / drug therapy* Osteoclasts / cytology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anthelmintics; 0/Anti-Infective Agents; 0/Antineoplastic Agents; 0/Cardiac Glycosides; 0/Cytokines; 0/Growth Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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