Document Detail

Cell-based bone reconstruction therapies-principles of clinical approaches.
MedLine Citation:
PMID:  17190299     Owner:  NLM     Status:  MEDLINE    
Cell-based bone tissue engineering is a rapidly evolving therapy option in bone reconstruction strategies. Some cell-driven approaches, especially the biophysical stimulation of the host cell population surrounded by the bone defect, are common treatment methods in maxillofacial surgery. Others, such as autologous cell implantation, have now gained acceptance for clinical trials. More advanced or complex therapeutical options (extracorporeal tissue engineering, stem cell use, genetic engineering) have been tested in preclinical investigations but have not reached the level of clinical use. Two different aspects are of special relevance in cell-based bone reconstruction therapies. The source of cells used to regenerate bone (discussed in detail in a complementary review in this issue of The International Journal of Oral and Maxillofacial Implants) as well as the principal approach of a cell-driven bone regeneration therapy influence the outcome of such engineering strategies. All of the cell-driven repair strategies are under intensive investigation in an effort to provide surgeons with a limitless supply of tissue for bone repair and reconstruction in future procedures. An overview of the basic biological aspects as well as the inherent constraints of different cell-based approaches are given in this paper.
Ulrich Meyer; Hans-Peter Wiesmann; Karin Berr; Norbert R Kübler; Jörg Handschel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The International journal of oral & maxillofacial implants     Volume:  21     ISSN:  0882-2786     ISO Abbreviation:  Int J Oral Maxillofac Implants     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-12-27     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611905     Medline TA:  Int J Oral Maxillofac Implants     Country:  United States    
Other Details:
Languages:  eng     Pagination:  899-906     Citation Subset:  D; IM    
Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-Universitat, Moorenstr. 5 (Gebaude 18.73), D-40225 Disseldorf, Germany.
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MeSH Terms
Bone Transplantation / methods
Bone and Bones / cytology,  surgery*
Cell Culture Techniques
Genetic Engineering
Reconstructive Surgical Procedures / methods*
Tissue Engineering / methods*

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