| Cell-based bone reconstruction therapies-principles of clinical approaches. | |
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MedLine Citation:
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PMID: 17190299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell-based bone tissue engineering is a rapidly evolving therapy option in bone reconstruction strategies. Some cell-driven approaches, especially the biophysical stimulation of the host cell population surrounded by the bone defect, are common treatment methods in maxillofacial surgery. Others, such as autologous cell implantation, have now gained acceptance for clinical trials. More advanced or complex therapeutical options (extracorporeal tissue engineering, stem cell use, genetic engineering) have been tested in preclinical investigations but have not reached the level of clinical use. Two different aspects are of special relevance in cell-based bone reconstruction therapies. The source of cells used to regenerate bone (discussed in detail in a complementary review in this issue of The International Journal of Oral and Maxillofacial Implants) as well as the principal approach of a cell-driven bone regeneration therapy influence the outcome of such engineering strategies. All of the cell-driven repair strategies are under intensive investigation in an effort to provide surgeons with a limitless supply of tissue for bone repair and reconstruction in future procedures. An overview of the basic biological aspects as well as the inherent constraints of different cell-based approaches are given in this paper. |
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Authors:
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Ulrich Meyer; Hans-Peter Wiesmann; Karin Berr; Norbert R Kübler; Jörg Handschel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The International journal of oral & maxillofacial implants Volume: 21 ISSN: 0882-2786 ISO Abbreviation: Int J Oral Maxillofac Implants Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-12-27 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611905 Medline TA: Int J Oral Maxillofac Implants Country: United States |
Other Details:
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Languages: eng Pagination: 899-906 Citation Subset: D; IM |
Affiliation:
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Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-Universitat, Moorenstr. 5 (Gebaude 18.73), D-40225 Disseldorf, Germany. Ulrich.meyer@med.uni-duesseldorf.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Transplantation / methods Bone and Bones / cytology, surgery* Cell Culture Techniques Genetic Engineering Humans Reconstructive Surgical Procedures / methods* Tissue Engineering / methods* |
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