Document Detail


Cell-based biosensors: current trends of the development.
MedLine Citation:
PMID:  20799198     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In the last decade, a number of laboratories have developed devices that combine electronic components with living cells, including neurons. These devices can be used as cell-based biosensors or labs-on-a-chip for testing of the tumor cell sensitivity to anti-cancer drugs, detection of toxins and chemical substances and pre-clinical evaluation of new drugs. Here we review briefly the existing types of the cell-based biosensors and the strategies employed to improve these complex devices. We argue that, for the neuron-based biosensors, introduction of structure in the connections of the synaptic network should significantly improve the utility of such devices.
Authors:
G Baranauskas; R Gusmeroli; A S Spinelli; C Giordano; M T Raimondi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied biomaterials & biomechanics : JABB     Volume:  4     ISSN:  1722-6899     ISO Abbreviation:  J Appl Biomater Biomech     Publication Date:    2006 Sep-Dec
Date Detail:
Created Date:  2010-08-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101180437     Medline TA:  J Appl Biomater Biomech     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  125-34     Citation Subset:  -    
Affiliation:
Department of Chemistry, Materials and Chemical Engineering ""G.Natta"", Politecnico di Milano, Milano - Italy.
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