| The Cell-Type Specific Cortical Microcircuit: Relating Structure and Activity in a Full-Scale Spiking Network Model. | |
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MedLine Citation:
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PMID: 23203991 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the past decade, the cell-type specific connectivity and activity of local cortical networks have been characterized experimentally to some detail. In parallel, modeling has been established as a tool to relate network structure to activity dynamics. While available comprehensive connectivity maps ( Thomson, West, et al. 2002; Binzegger et al. 2004) have been used in various computational studies, prominent features of the simulated activity such as the spontaneous firing rates do not match the experimental findings. Here, we analyze the properties of these maps to compile an integrated connectivity map, which additionally incorporates insights on the specific selection of target types. Based on this integrated map, we build a full-scale spiking network model of the local cortical microcircuit. The simulated spontaneous activity is asynchronous irregular and cell-type specific firing rates are in agreement with in vivo recordings in awake animals, including the low rate of layer 2/3 excitatory cells. The interplay of excitation and inhibition captures the flow of activity through cortical layers after transient thalamic stimulation. In conclusion, the integration of a large body of the available connectivity data enables us to expose the dynamical consequences of the cortical microcircuitry. |
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Authors:
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Tobias C Potjans; Markus Diesmann |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-2 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: - ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Neuroscience and Medicine (INM-6), Computational and Systems Neuroscience, Research Center Juelich, Juelich, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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