Document Detail


Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells.
MedLine Citation:
PMID:  22574986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelial progenitor cells (EPCs) correspond to a population of cells with novel properties capable of angiogenesis and vasculogenesis, thus they are likely to display unique role in the reconstitution of the blood brain barrier (BBB) after stroke. Laboratory evidence supports safety and efficacy of cell therapy for stroke, with limited clinical trials recently initiated. This lab-to-clinic ascent of cell-based therapeutics has been aided by the establishment of consortium consisting of thought-leaders from academia, industry, National Institutes of Health (NIH) and the United States Food and Drug Administration (FDA). However, there remain unanswered questions prior to realization of large-scale application of cell transplantation in patients. This review article discusses translational challenges associated in cell therapy, emphasizing the need for optimizing both safety and efficacy profiles for advancing the clinical applications of EPC transplantation for stroke patients.
Authors:
Yuji Kaneko; Naoki Tajiri; Kazutaka Shinozuka; Loren E Glover; Nathan L Weinbren; Lourdes Cortes; Cesar V Borlongan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  18     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-12-26     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3731-4     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, Florida 33612, USA.
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MeSH Terms
Descriptor/Qualifier:
Endothelial Cells / cytology*
Humans
Stem Cell Transplantation*
Stroke / therapy*
Grant Support
ID/Acronym/Agency:
R01 NS071956/NS/NINDS NIH HHS; R01NS071956-01/NS/NINDS NIH HHS; UO15U01NS055914-04/NS/NINDS NIH HHS
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