Document Detail


β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia.
MedLine Citation:
PMID:  22164158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On system under the control of the proinsulin promoter to selectively overexpress GPR39 in the β cells in a double transgenic mouse strain and challenge them with multiple low doses of streptozotocin, which in the wild-type littermates leads to a gradual increase in nonfasting glucose levels and glucose intolerance observed during both food intake and OGTT. Although the overexpression of the constitutively active GPR39 receptor in animals not treated with streptozotocin appeared by itself to impair the glucose tolerance slightly and to decrease the β-cell mass, it nevertheless totally protected against the gradual hyperglycemia in the steptozotocin-treated animals. It is concluded that GPR39 functions in a β-cell protective manner and it is suggested that it is involved in some of the beneficial, β-cell protective effects observed for Zn(++) and that GPR39 may be a target for antidiabetic drug intervention.
Authors:
Kristoffer L Egerod; Chunyu Jin; Pia Steen Petersen; Nils Wierup; Frank Sundler; Birgitte Holst; Thue W Schwartz
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Publication Detail:
Type:  Journal Article     Date:  2011-11-17
Journal Detail:
Title:  International journal of endocrinology     Volume:  2011     ISSN:  1687-8345     ISO Abbreviation:  Int J Endocrinol     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101516376     Medline TA:  Int J Endocrinol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  401258     Citation Subset:  -    
Affiliation:
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.
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