Document Detail


Cell Reconstruction of the Rectal Mucosa in Patients with Familial Adenomatous Polyposis: Endoscopy, Morphology, Immunohistochemistry.
MedLine Citation:
PMID:  25257440     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells of the intestinal epithelium and mesenchymal cells of various origin is used. The mechanisms of mucosa reparation were studied in 34 patients. Endoscopic, morphological, and immunohistochemical studies showed that cell transplantation considerably accelerated reparation of the mucosa in mucosectomized rectum. The proposed treatment of familial colorectal adenomatous polyposis allows delaying the development of rectal polyps and cancer for many years.
Authors:
E A Kogan; D V Vyshegorodtsev; N M Faizullina; T A Demura; A M Kuz'minov; Yu A Shelygin; G T Sukhikh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-26
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  -     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-26     Completed Date:  -     Revised Date:  2014-9-27    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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