| Cell Penetrating Peptides for Tumor Targeting. | |
| | |
MedLine Citation:
|
PMID: 21470141 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy. While different types of transporters currently exist, cell penetrating peptides (CPPs) have become one of the most popular and effective tools for intracellular drug delivery. Most of the original CPPs are short peptides with basic residues. The mechanism of CPP cell entry remains to be established; however, the CPPs can deliver any type of molecular cargo including solid nanoparticles. Herein, this paper will discuss the classification of CPPs, the mechanism of cell entry, the application of CPPs in tumor therapy, and recent advances in targeted cell penetration that involve CPPs. |
| | |
Authors:
|
Young Suk Choi; Jue Yeon Lee; Jin Sook Suh; Seung Jin Lee; Victor C Yang; Chong Pyoung Chung; Yoon Jeong Park |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-6 |
Journal Detail:
|
Title: Current pharmaceutical biotechnology Volume: - ISSN: 1873-4316 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Dental Regenerative Biotechnology, Dental Research Institute and School of Dentistry, Seoul National University, 28-2 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea. parkyj@snu.ac.kr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Promises of Apoptosis-Inducing Peptides in Cancer Therapeutics.
Next Document: Self-Assembling Peptides: Potential Role in Tumor Targeting.