Document Detail


Cell-Penetrable Lysine Dendrimers for Anti-Cancer Drug Delivery: Synthesis and Preliminary Biological Evaluation.
MedLine Citation:
PMID:  24740712     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Improving the cell penetration and enhancing the cell selectivity of drugs have been approved for overcoming the major drawbacks of chemotherapeutic agents: the toxicity to normal cells and the drug resistance in tumors. In this paper, lysine dendrimers (G1-G3) were chosen as novel cell-penetrating carriers for anti-cancer drugs based on the internalization mechanism of cell-penetrating peptides and the characteristics of dendritic peptides. After labeling with fluorescein isothiocyanate (FITC), the cell-penetrable capacity of lysine dendrimers was certified by flow cytometric analysis. In a preliminary biological evaluation, the conjugates of lysine dendrimers and 5-fluorouracil showed the expected advantages: stable drug release, low toxicity to normal cells, and moderate inhibition of tumor cells. These results imply that cell-penetrable lysine dendrimers could be potential carriers in drug delivery of anti-cancer medicine.
Authors:
Jing Zhao; Rui Zhou; Xiaoyu Fu; Wen Ren; Lifang Ma; Ran Li; Yi Zhao; Li Guo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-17
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  -     ISSN:  1521-4184     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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