Document Detail

Cell fusion-induced activation of interferon-stimulated genes is not required for restriction of a herpes simplex virus VP16/ICP0 mutant in heterokarya formed between permissive and restrictive cells.
MedLine Citation:
PMID:  19535444     Owner:  NLM     Status:  MEDLINE    
Herpes simplex virus VP16 and ICP0 mutants replicate efficiently in U2OS osteosarcoma cells but are restricted in other cell types. We previously showed that the restrictive phenotype is dominant in a transient cell fusion assay, suggesting that U2OS cells lack an antiviral mechanism present in other cells. Recent data indicate that unscheduled membrane fusion events can activate the expression of interferon-stimulated genes (ISGs) in fibroblasts, raising the possibility that our earlier results were due to a fusion-induced antiviral state. However, we show here that the permissive phenotype is also extinguished following fusion with Vero cells in the absence of ISG induction.
Meaghan H Hancock; Karen L Mossman; James R Smiley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-17
Journal Detail:
Title:  Journal of virology     Volume:  83     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-08-31     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8976-9     Citation Subset:  IM    
Alberta Institute for Viral Immunology, Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.
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MeSH Terms
Cell Fusion*
Cell Line, Tumor
Cercopithecus aethiops
Herpes Simplex Virus Protein Vmw65 / deficiency*
Immediate-Early Proteins / deficiency*
Interferons / biosynthesis*
Simplexvirus / immunology*,  physiology*
Ubiquitin-Protein Ligases / deficiency*
Vero Cells
Virus Replication*
Reg. No./Substance:
0/Herpes Simplex Virus Protein Vmw65; 0/Immediate-Early Proteins; 9008-11-1/Interferons; EC Ligases; EC protein, Human herpesvirus 1

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