| Cell-derived microparticles promote coagulation after moderate exercise. | |
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MedLine Citation:
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PMID: 21131870 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSES: : This study aimed to examine (i) the concentration and procoagulant activity of cell-derived MP after a moderate endurance exercise and (ii) the differences in the release, clearance, and activity of MP before and after exercise between trained and untrained individuals. METHODS: : All subjects performed a single bout of physical exercise on a bicycle ergometer for 90 min at 80% of their individual anaerobic threshold. MP were identified and quantified by flow cytometry measurements. Procoagulant activity of MP was measured by a prothrombinase activity assay as well as tissue factor-induced fibrin formation in MP-containing plasma. RESULTS: : At baseline, no differences were observed for the absolute number and procoagulant activities of MP between trained and untrained subjects. However, trained individuals had a lower number of tissue factor-positive monocyte-derived MP compared with untrained individuals. In trained subjects, exercise induced a significant increase in the number of MP derived from platelets, monocytes, and endothelial cells, with maximum values at 45 min after exercise and returned to basal levels at 2 h after exercise. Untrained subjects revealed a similar increase in platelet-derived MP, but their level was still increased at 2 h after exercise, indicating a reduced clearance compared with trained individuals. Procoagulant activities of MP were increased immediately after exercise and remained elevated up to 2 h after exercise. CONCLUSIONS: : We conclude that increased levels of MP were found in healthy individuals after an acute bout of exercise, that the amount of circulating MP contributes to an exercise-induced increase of hemostatic potential, and that there were differences in kinetic and dynamic characteristics between trained and untrained individuals. |
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Authors:
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Maik Sossdorf; Gordon P Otto; Ralf A Claus; Holger H W Gabriel; Wolfgang Lösche |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 43 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1169-76 Citation Subset: IM; S |
Affiliation:
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1Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, GERMANY; and 2Department of Sports Medicine, Institute of Sports Science, Jena Friedrich-Schiller University, Jena, GERMANY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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