Document Detail

Cell delivery routes for stem cell therapy to the heart: current and future approaches.
MedLine Citation:
PMID:  22648235     Owner:  NLM     Status:  MEDLINE    
An important factor to determine the success of stem cell therapy to the heart is the choice of cell delivery route. This will affect the fate of donor cells and subsequently influence the outcome of treatment; however, there is currently no optimum cell delivery route appropriate for every disease condition or every donor cell type. This review summarises currently available approaches for administering cells to the heart, with a particular focus on cell retention/survival and the therapeutic benefits seen in preclinical and clinical studies. Two major approaches are intracoronary and intramyocardial injection, which have been widely used for the delivery of various types of cells. Although there are advantages to both approaches, donor cell retention and survival are poor using these methods, potentially limiting therapeutic effects. Various attempts to improve current approaches, along with the development of emerging new approaches, are also described and discussed in this review.
Niall G Campbell; Ken Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-31
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  5     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-20     Completed Date:  2013-02-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-26     Citation Subset:  IM    
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MeSH Terms
Cardiac Catheterization
Heart Diseases / pathology,  physiopathology,  surgery*
Injections, Intra-Arterial
Injections, Intramuscular
Myocardium / pathology*
Recovery of Function
Regenerative Medicine
Stem Cell Transplantation / methods*
Treatment Outcome
Grant Support
G116/158//Medical Research Council; L018//Department of Health; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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