| Cell cycle regulation by MicroRNAs in embryonic stem cells. | |
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MedLine Citation:
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PMID: 19435891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell cycle is tightly orchestrated during normal development. Embryonic stem (ES) cells have a unique cell cycle structure, in which the G1/S restriction is largely absent, enabling cells to rapidly move through the G1 phase and enter the S phase. This hastened cell cycle allows the early embryo to rapidly grow. Recent experiments suggest that small noncoding RNAs, the microRNAs (miRNAs), play a central role in achieving this unique cell cycle structure. The responsible miRNAs function by suppressing multiple inhibitors of the G1/S transition. Expression of these miRNAs drops dramatically as the ES cells differentiate and as the G1 phase extends. Some of the same miRNAs are overexpressed in cancers, in which they can promote tumor growth, suggesting common mechanisms of miRNA-regulated cell cycle control in ES cells and cancers. This review discusses these recent findings in the context of broader knowledge of cell cycle control in normal and abnormal development. |
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Authors:
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Yangming Wang; Robert Blelloch |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-05-12 |
Journal Detail:
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Title: Cancer research Volume: 69 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-07-08 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 4093-6 Citation Subset: IM |
Affiliation:
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The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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physiology* Cell Division Embryonic Stem Cells / cytology, physiology* Genome Germ Cells / physiology Humans MicroRNAs / genetics* Neoplasms / genetics, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS048118-04/NS/NINDS NIH HHS; K08 NS48118/NS/NINDS NIH HHS; R01 NS057221/NS/NINDS NIH HHS; R01 NS057221-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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