| The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. | |
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MedLine Citation:
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PMID: 19664987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pluripotent stem cells have long-term proliferative capacity and an unusual mode of cell-cycle regulation and can divide independently of extrinsic mitogenic signals. The last few years has seen evidence emerge that links cell-cycle regulation to the maintenance and establishment of pluripotency. Myc transcription factors appear to be central to this regulation. This review addresses these links and discusses how cell-cycle controls and Myc impact on the maintenance and establishment of pluripotency. |
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Authors:
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Amar M Singh; Stephen Dalton |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cell stem cell Volume: 5 ISSN: 1875-9777 ISO Abbreviation: Cell Stem Cell Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-10-21 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101311472 Medline TA: Cell Stem Cell Country: United States |
Other Details:
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Languages: eng Pagination: 141-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Paul D. Coverdell Center for Biomedical and Health Sciences, The University of Georgia, Athens, GA 30602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Differentiation / physiology* Cell Proliferation Humans Nuclear Reprogramming / physiology* Pluripotent Stem Cells / physiology* Proto-Oncogene Proteins c-myc / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM75334/GM/NIGMS NIH HHS; HD049647/HD/NICHD NIH HHS; P01 GM085354-01/GM/NIGMS NIH HHS; P01 GM085354-010001/GM/NIGMS NIH HHS; P01 GM085354-020001/GM/NIGMS NIH HHS; P01 GM085354-02S1/GM/NIGMS NIH HHS; P01 GM085354-02S10001/GM/NIGMS NIH HHS; P01 GM085354-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-myc |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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