| Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis. | |
| | |
MedLine Citation:
|
PMID: 21052502 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered. |
| | |
Authors:
|
Ashley A Kowalewski; R Lor Randall; Stephen L Lessnick |
Publication Detail:
|
Type: Journal Article Date: 2010-11-01 |
Journal Detail:
|
Title: Sarcoma Volume: 2011 ISSN: 1369-1643 ISO Abbreviation: Sarcoma Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: 2011-07-14 Revised Date: 2012-01-09 |
Medline Journal Info:
|
Nlm Unique ID: 9709257 Medline TA: Sarcoma Country: Egypt |
Other Details:
|
Languages: eng Pagination: 598704 Citation Subset: - |
Affiliation:
|
Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
R01 CA140394-03/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Syphilitic coronary artery ostial stenosis resulting in acute myocardial infarction treated by percu...
Next Document: Diesel engine exhaust initiates a sequence of pulmonary and cardiovascular effects in rats.