| Review: cell cycle aberrations and neurodegeneration. | |
| | |
MedLine Citation:
|
PMID: 20059701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The cell cycle is a highly regulated and fundamental cellular process that involves complex feedback regulation of many proteins, and any compromise to its integrity elicits dire consequences for the cell. For example, in neurodegenerative diseases such as Alzheimer disease (AD), evidence for abnormal cell cycle re-entry precedes other hallmarks of disease and as such, implicates cell cycle aberrations in the aetiology of AD. The mechanism(s) for cell cycle re-entry in AD, however, remain unclear. Current theory suggests it to be part of a combination of early events that together elicit the degenerative pathology and cognitive phenotype consistent with the disease. We propose a 'Two-Hit Hypothesis' that highlights the concerted interaction between cell cycle alterations and oxidative stress that combine to produce neurodegeneration. Here, we review the evidence implicating cell cycle mechanisms in AD and how such changes, especially in combination with oxidative stress, would lead to a cascade of events leading to disease. Based on this concept, we propose new opportunities for disease treatment. |
| | |
Authors:
|
D J Bonda; V P Bajić; B Spremo-Potparevic; G Casadesus; X Zhu; M A Smith; H-G Lee |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-01-06 |
Journal Detail:
|
Title: Neuropathology and applied neurobiology Volume: 36 ISSN: 1365-2990 ISO Abbreviation: Neuropathol. Appl. Neurobiol. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-26 Completed Date: 2010-07-19 Revised Date: 2010-12-17 |
Medline Journal Info:
|
Nlm Unique ID: 7609829 Medline TA: Neuropathol Appl Neurobiol Country: England |
Other Details:
|
Languages: eng Pagination: 157-63 Citation Subset: IM |
Affiliation:
|
Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
physiopathology,
therapy Animals Cell Cycle / physiology* Humans Nerve Degeneration / physiopathology, therapy Neurodegenerative Diseases / physiopathology*, therapy Neurons / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
AG028679/AG/NIA NIH HHS; AG030096/AG/NIA NIH HHS; AG031364/AG/NIA NIH HHS; R01 AG028679-04/AG/NIA NIH HHS; R21 AG030096-02/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Riser's reflux - an eye-opening experience.
Next Document: Presence of three mycorrhizal genes in the common ancestor of land plants suggests a key role of myc...