Document Detail


Cell-based therapy for prevention and reversal of myocardial remodeling.
MedLine Citation:
PMID:  22636682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although pharmacological and interventional advances have reduced the morbidity and mortality of ischemic heart disease, there is an ongoing need for novel therapeutic strategies that prevent or reverse progressive ventricular remodeling following myocardial infarction, the process that forms the substrate for ventricular failure. The development of cell-based therapy as a strategy to repair or regenerate injured tissue offers extraordinary promise for a powerful anti-remodeling therapy. In this regard, the field of cell therapy has made major advancements in the past decade. Accumulating data from preclinical studies have provided novel insights into stem cell engraftment, differentiation, and interactions with host cellular elements, as well as the effectiveness of various methods of cell delivery and accuracy of diverse imaging modalities to assess therapeutic efficacy. These findings have in turn guided rationally designed translational clinical investigations. Collectively, there is a growing understanding of the parameters that underlie successful cell-based approaches for improving heart structure and function in ischemic and other cardiomyopathies.
Authors:
Vasileios Karantalis; Wayne Balkan; Ivonne H Schulman; Konstantinos E Hatzistergos; Joshua M Hare
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review; Webcasts     Date:  2012-05-25
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2012-10-10     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H256-70     Citation Subset:  IM    
Affiliation:
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Florida, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / pathology,  physiopathology,  surgery*
Cell Differentiation
Cell Proliferation
Cell Survival
Humans
Myocardial Ischemia / pathology,  physiopathology,  surgery*
Myocardium / pathology*
Recovery of Function
Regeneration
Stem Cell Transplantation*
Treatment Outcome
Ventricular Remodeling*
Grant Support
ID/Acronym/Agency:
P20-HL-101443/HL/NHLBI NIH HHS; R01 HL107110/HL/NHLBI NIH HHS; R01-HL-084275/HL/NHLBI NIH HHS; R01-HL-094849/HL/NHLBI NIH HHS; R01-HL-107110/HL/NHLBI NIH HHS; R01-HL-110737/HL/NHLBI NIH HHS
Comments/Corrections

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