Document Detail


Cell-Based Reparative Therapies for Multiple Sclerosis.
MedLine Citation:
PMID:  24078453     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The strong rationale for cell-based therapy in multiple sclerosis is based on the ability of stem and precursor cells of neural and mesenchymal origin to attenuate neuroinflammation, to facilitate endogenous repair processes, and to participate directly in remyelination, if directed towards a myelin-forming fate. However, there are still major gaps in knowledge regarding induction of repair in chronic multiple sclerosis lesions, and whether transplanted cells can overcome the multiple environmental inhibitory factors which underlie the failure of endogenous repair. Major challenges in clinical translation include the determination of the optimal cellular platform, the route of cell delivery, and candidate patients for treatment.
Authors:
Tamir Ben-Hur; Nina Fainstein; Yossi Nishri
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-9-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  397     Citation Subset:  -    
Affiliation:
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel, tamir@hadassah.org.il.
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