Document Detail


Celiprolol, a compound which attenuates myocardial acidosis and improves regional segmental function following ischemia in dogs: a comparison with propranolol.
MedLine Citation:
PMID:  2573907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Celiprolol, propranolol or saline were administered to separate groups (n = 5-6) of anesthetized dogs in which a critical stenosis was applied to the circumflex coronary artery for 90 min and then reperfused for 30 min. Test drugs were administered at 30 min poststenosis and the effects on pH, regional function and endocardiogram were monitored. A reduction in coronary flow of 54 +/- 2% (n = 27) yielded marked increases in hydrogen ion concentration (H+) of 17 +/- 2 X 10(-8) and ischemic endocardial ST segment of 6 +/- 1 mV while ischemic segmental shortening decreased 75 +/- 9%. Heart rate, arterial pressure and normal regional function were not altered. Celiprolol 0.1 and 1 mg/kg, i.v., reversed the alterations in H+ and ischemic ST segment to prestenosis values while improving ischemic segmental shortening 20 and 38%, respectively, and not affecting heart rate. Propranolol 0.1 and 1 mg/kg, i.v., reversed the alterations in H+ and ischemic ST segment to prestenosis values while further decreasing ischemic segmental shortening 66 and 30%, respectively. Upon reperfusion, ischemic segmental shortening returned to prestenosis values in the group treated with celiprolol 1 mg/kg, i.v., while the propranolol- and saline-treated groups further decreased. It is concluded that celiprolol is efficacious in normalizing myocardial function and ischemia-induced electrophysiological changes following coronary artery stenosis.
Authors:
J A Barrett; A M Magistro; R D Smith; T P Pruss; P S Wolf
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  39     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-09     Completed Date:  1990-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Pharmacology, Rorer Central Research, Horsham, Pa.
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MeSH Terms
Descriptor/Qualifier:
Acidosis / drug therapy*
Adrenergic alpha-Antagonists / therapeutic use*
Animals
Blood Pressure / drug effects
Body Temperature / drug effects
Cardiomyopathies / drug therapy*
Celiprolol
Coronary Circulation / drug effects
Coronary Disease / drug therapy*,  physiopathology
Dogs
Electrocardiography
Female
Heart Rate / drug effects
Hydrogen-Ion Concentration
Male
Propanolamines / therapeutic use*
Propranolol / therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Propanolamines; 525-66-6/Propranolol; 56980-93-9/Celiprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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