Document Detail


Celiac neuropathy.
MedLine Citation:
PMID:  12771245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Celiac disease (CD) is a chronic inflammatory enteropathy resulting from sensitivity to ingested gluten. Neurologic complications are estimated to occur in 10% of affected patients, with ataxia and peripheral neuropathy being the most common problems. The incidence and clinical presentation of patients with CD-associated peripheral neuropathy have not previously been investigated. OBJECTIVE: To determine the incidence of CD in patients with neuropathy and to characterize the clinical presentation. METHODS: The records of 20 patients with neuropathy and biopsy-confirmed CD were reviewed. RESULTS: Six of the 20 patients had neuropathic symptoms alone without gastrointestinal involvement, and neuropathic symptoms preceded other CD symptoms in another 3 patients. All patients had burning, tingling, and numbness in their hands and feet, with distal sensory loss, and nine had diffuse paresthesias involving the face, trunk, or lumbosacral region. Only two had weakness. Results of electrophysiologic studies were normal or mildly abnormal in 18 (90%) of the patients. Sural nerve biopsies, obtained from three patients, revealed mild to severe axonopathy. Using the agglutination assay, 13 (65%) of the patients were positive for ganglioside antibodies. Excluding patients who were referred with the diagnosis of celiac neuropathy, CD was seen in approximately 2.5% of all neuropathy patients and in 8% of patients with neuropathy and normal electrophysiologic studies seen at our center. CONCLUSION: CD is commonly associated with sensory neuropathy and should be considered even in the absence of gastrointestinal symptoms.
Authors:
R L Chin; H W Sander; T H Brannagan; P H R Green; A P Hays; A Alaedini; N Latov
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurology     Volume:  60     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2004-01-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1581-5     Citation Subset:  AIM; IM    
Affiliation:
Peripheral Neuropathy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10022, USA. RUC9002@med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibody Specificity
Biopsy
Celiac Disease / complications*,  diet therapy,  immunology
Female
Gait Disorders, Neurologic / etiology*,  immunology
Gangliosides / immunology
Gliadin / immunology
Glutens / adverse effects
Humans
Immunoglobulin A / immunology
Male
Middle Aged
Paresthesia / etiology*,  immunology
Retrospective Studies
Sural Nerve / pathology
Transglutaminases / immunology
Chemical
Reg. No./Substance:
0/Gangliosides; 0/Immunoglobulin A; 8002-80-0/Glutens; 9007-90-3/Gliadin; EC 2.3.2.13/Transglutaminases
Comments/Corrections
Comment In:
Neurology. 2003 May 27;60(10):1566-8   [PMID:  12771239 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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