Document Detail


Celiac disease-related antibodies in an epilepsy cohort and matched reference population.
MedLine Citation:
PMID:  15820348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Celiac disease (CD) is a common immunologically mediated enteropathic condition manifesting in genetically predisposed individuals after exposure to wheat gluten. CD may be associated with a number of neurological disorders, and the prevalence of epilepsy is reported to be increased in patients with CD. We studied the prevalence of CD-associated antibodies in a cohort of 968 patients with epilepsy and in a population-based reference group of 584 subjects. There was no difference in the prevalence of IgA and IgG class antigliadin antibodies (AGAbA and AGAbG, respectively), endomysial antibodies (EMA), and tissue transglutaminase antibodies (tTGAbA) between patients with epilepsy and the control population. This suggests the presence of CD to be the same in patients with epilepsy and the reference population. However, AGAbA was more prevalent in patients with primary generalized epilepsy (19.6%) than in the reference population (10.6%, relative risk 1.8, 95% confidence interval 1.1-3.0, P=0.012).
Authors:
Jouni Ranua; Katja Luoma; Anssi Auvinen; Markku Mäki; Anna-Maija Haapala; Jukka Peltola; Jani Raitanen; Jouko Isojärvi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  6     ISSN:  1525-5050     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-06-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  388-92     Citation Subset:  IM    
Affiliation:
Department of Neurology, Seinäjoki Central Hospital, Seinä-joki, Finland. jouni.ranua@netikka.fi
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MeSH Terms
Descriptor/Qualifier:
Antibodies / classification,  metabolism*
Autoantibodies / immunology
Case-Control Studies
Celiac Disease / epidemiology,  immunology*
Cohort Studies
Confidence Intervals
Enzyme-Linked Immunosorbent Assay / methods
Epilepsy / epidemiology,  immunology*
Gliadin / immunology
Humans
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Muscle Fibers, Skeletal / immunology
Odds Ratio
Population Surveillance
Prevalence
Transglutaminases / immunology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Autoantibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 9007-90-3/Gliadin; EC 2.3.2.13/Transglutaminases

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