Document Detail

Celiac disease and intestinal metaplasia of the esophagus (Barrett's esophagus).
MedLine Citation:
PMID:  15712649     Owner:  NLM     Status:  MEDLINE    
Previous studies on celiac patients demonstrated that exposure to gliadin alters the motility of the upper gastrointestinal tract, leading to increased acid reflux. No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 +/- 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 +/- 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin.
Roberto Maieron; Luca Elli; Marco Marino; Irene Floriani; Francesco Minerva; Claudio Avellini; Giovanni Falconieri; Stefano Pizzolitto; Maurizio Zilli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  50     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-16     Completed Date:  2005-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126-9     Citation Subset:  AIM; IM    
Gastroenterology Unit, General Hospital S. M. della Misericordia, Udine, Italy.
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MeSH Terms
Aged, 80 and over
Barrett Esophagus / complications,  epidemiology,  pathology*
Celiac Disease / complications*,  pathology*
Esophagus / pathology
Middle Aged

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