Document Detail


Celiac disease in patients with presumed irritable bowel syndrome: a case-finding study.
MedLine Citation:
PMID:  19908341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To estimate the prevalence of celiac disease (CD) in adult patients with presumed irritable bowel syndrome (IBS). METHODS: Between March 2005 and December 2008, 742 consecutive patients (293 male, median age 43 years, range 18-69 years) fulfilling the Rome II criteria for IBS were prospectively enrolled in the study. IBS was diagnosed via self-completed Rome II modular questionnaires. Anti-tissue transglutaminase (anti-tTG) serology was checked to initially recognize possible CD cases. Patients with a positive test were offered endoscopic duodenal biopsy to confirm the diagnosis of CD. RESULTS: Thirty two patients (15 male, median age 41 years, range 19-59 years) were found to have organic diseases other than CD. Twenty four patients tested positive for anti-tTG antibodies, and duodenal biopsies confirmed the diagnosis in all of them. Thus, in this patient population with presumed IBS, 3.23% actually had CD. CONCLUSION: CD is common in patients with presumed IBS. Routine screening for CD in patients with symptoms of IBS is recommended.
Authors:
Khaled Ali Jadallah; Yousef Saleh Khader
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2010-02-25     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5321-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan. khaled-j@just.edu.jo
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Biopsy
Celiac Disease / blood,  epidemiology*,  pathology
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin A / blood*
Immunoglobulin G / blood*
Irritable Bowel Syndrome / epidemiology*,  pathology
Male
Middle Aged
Prevalence
Prospective Studies
Transglutaminases / immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; EC 2.3.2.13/Transglutaminases
Comments/Corrections

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