| Celiac disease: evaluation with dynamic contrast-enhanced MR imaging. | |
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MedLine Citation:
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PMID: 20663971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively determine mural perfusion dynamics in patients with untreated celiac disease by using dynamic contrast material-enhanced magnetic resonance (MR) imaging and to compare these dynamics with those in a control population and in patients with celiac disease treated with a gluten-free diet. MATERIALS AND METHODS: Institutional review board approval and informed consent from all participants were obtained. Sixty consecutive patients with untreated celiac disease, 45 patients with celiac disease treated with a gluten-free diet for at least 1 year, and 30 control subjects were enrolled in this study. Dynamic contrast-enhanced MR imaging was performed by using a 1.5-T MR unit. For each MR imaging examination, maximum enhancement, slope of enhancement, and time-signal intensity curves were calculated at the level of the descending duodenal wall. Duodenal wall thickness was also evaluated. Statistical evaluation was performed by using one-way analysis of variance, and the results were confirmed by using the Bartlett test for equal variances and complemented by using Bonferroni multiple comparison, linear correlation, and the Student t test for paired data. RESULTS: Mean maximum enhancement of the duodenal wall was significantly higher in patients with untreated celiac disease (229.1 +/- 46.4 [standard deviation]) than in patients with treated celiac disease (109.8 +/- 27.8) and control subjects (94.7 +/- 17.9) (P < .001 for each comparison). All 60 untreated patients showed a curve characterized by fast enhancement and washout (type 4), while all 45 treated patients and the 30 control subjects showed a curve characterized by slow constant enhancement (type 2). Mean duodenal wall thickness was not significantly different between untreated patients (2.2 mm +/- 0.4), treated patients (2.0 mm +/- 0.3), and control subjects (2.0 mm +/- 0.4) (one-way analysis of variance, P = .4177; Bartlett test, P = .6951). CONCLUSION: The results of this study suggest that dynamic evaluation of the bowel wall by using contrast-enhanced MR imaging can be an effective and reproducible way to show the inflammation state in celiac disease. |
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Authors:
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Gabriele Masselli; Antonio Picarelli; Marco Di Tola; Valerio Libanori; Giuseppe Donato; Elisabetta Polettini; Alessandra Piermattei; Piergaspare Palumbo; Angelo Pittalis; Annarita Saponara; Gianfranco Gualdi |
Publication Detail:
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Type: Journal Article Date: 2010-07-27 |
Journal Detail:
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Title: Radiology Volume: 256 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 783-90 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2010. |
Affiliation:
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Department of Radiology, Gastroenterology, and Surgery, Umberto I Hospital, La Sapienza University, Rome, Italy. gabrielemasselli@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Biopsy Celiac Disease / diet therapy, pathology* Contrast Media Diet, Gluten-Free Electrolytes / diagnostic use Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging / methods* Male Meglumine / diagnostic use Middle Aged Organometallic Compounds / diagnostic use Polyethylene Glycols / diagnostic use Prospective Studies Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Electrolytes; 0/Golytely; 0/Organometallic Compounds; 0/Polyethylene Glycols; 0/gadoterate meglumine; 6284-40-8/Meglumine |
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