Document Detail


Celecoxib reduces fluidity and decreases metastatic potential of colon cancer cell lines irrespective of COX-2 expression.
MedLine Citation:
PMID:  21401528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Celecoxib, a selective COX-2 inhibitor, has numerous pleiotropic effects on the body which may be independent of its COX-2 inhibitory activity. The cancer chemopreventive ability of CLX, particularly in colorectal cancer (CRC), has been shown in epidemiological studies. Here were have, for the first time, examined the biophysical effects of CLX on the cellular membranes of COX-2 expressing (HT29) and COX-2 non-expressing (SW620) cells lines using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and spin label electron spin resonance spectroscopy (SL-ESR). Our data show that CLX treatment decreased lipid fluidity in the cancer cell lines irrespective of COX-2 expression status. As metastatic cells have higher membrane fluidity, we examined the effect of CLX on the metastatic potential of these cells. CLX treatment efficiently decreased the proliferation, anchorage independent growth, ability to close a scratch wound and migration and invasion of the CRC cell lines through Matrigel. We propose that one of the ways by which CLX exerts its antitumorigenic effects is via alterations in cellular membrane fluidity which has a notable impact on the cells' metastatic potential.
Authors:
Asli Sade; Seda Tuncay; Ismail Cimen; Feride Severcan; Sreeparna Banerjee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  Bioscience reports     Volume:  -     ISSN:  1573-4935     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102797     Medline TA:  Biosci Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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