| Celecoxib nanoemulsion: skin permeation mechanism and bioavailability assessment. | |
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MedLine Citation:
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PMID: 18985507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to assess the skin permeation mechanism and bioavailability of celecoxib (CXB) using novel nanoemulsion formulation. Fourier transform infrared spectra and differential scanning calorimetric thermogram of skin treated with nanoemulsion indicated that permeation occurred due to the extraction of stratum corneum (SC) lipids by nanoemulsion. The significant decrease in activation energy for CXB permeation across rat skin indicated that the SC lipid bilayers were significantly disrupted (p < 0.05). Photomicrograph of skin sample showed the disruption and extraction of lipid bilayers as distinct voids and empty spaces visible in the epidermal region. The absorption of CXB through transdermally applied nanoemulsion and nanoemulsion gel resulted in 3.03- and 2.65-fold increases in bioavailability when compared with conventional oral capsule formulation. Overall, these findings indicated that nanoemulsions can be successfully used for the enhancement of skin permeation and bioavailability of poorly soluble drugs. |
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Authors:
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Faiyaz Shakeel; Sanjula Baboota; Alka Ahuja; Javed Ali; Sheikh Shafiq |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of drug targeting Volume: 16 ISSN: 1029-2330 ISO Abbreviation: J Drug Target Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-13 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312476 Medline TA: J Drug Target Country: England |
Other Details:
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Languages: eng Pagination: 733-40 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Faculty of Pharmacy, Al-Arab Medical Sciences University, Benghazi, Libya. faiyazs@fastmail.fm |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Administration, Topical Animals Area Under Curve Biological Availability Emulsions / chemistry* Nanostructures / chemistry* Permeability Pyrazoles / administration & dosage*, blood, pharmacokinetics* Rats Skin / cytology, drug effects, metabolism* Sulfonamides / administration & dosage*, blood, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Pyrazoles; 0/Sulfonamides; 169590-42-5/celecoxib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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