Document Detail


Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression.
MedLine Citation:
PMID:  18343027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Celastrol, a compound purified from Tripterygium wilfordii whose preparations have been used for clinical treatment for rheumatoid arthritis, has been demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. However, whether its antiangiogenic activity plays a role in the celastrol-mediated suppression of tumor growth and the molecular basis of anti-tumor activity are poorly understood. In this study, we found that celastrol inhibited the growth of human glioma xenografts in mice, which concurred with the suppression of angiogenesis. Interestingly, while celastrol had no effect on either the expression of VEGF or its mRNA levels, celastrol treatment lowered the expression levels of its receptors (VEGFR-1 and VEGFR-2) and their mRNA levels. These findings suggest that celastrol have potential to be used as an antiangiogenesis drug through its role in suppressing VEGF receptors expression that might consequently reduce the signal transduction between VEGF and VEGFR.
Authors:
Yulun Huang; Youxin Zhou; Yisun Fan; Dai Zhou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-14
Journal Detail:
Title:  Cancer letters     Volume:  264     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-07-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
Affiliation:
Department of neurosurgery, The First Affiliated Hospital of Suzhou University, Suzhou, China. johnhyl@netase.com
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / chemistry,  pharmacology
Animals
Cell Line, Tumor
Cell Proliferation / drug effects
Down-Regulation / drug effects
Female
Glioma / drug therapy*,  pathology
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Structure
Receptors, Vascular Endothelial Growth Factor / drug effects,  genetics,  metabolism*
Transcription, Genetic
Triterpenes / chemistry,  pharmacology*
Tumor Burden
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Triterpenes; 34157-83-0/tripterine; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor

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