Document Detail


Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.
MedLine Citation:
PMID:  25284249     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Enoyl-acyl carrier protein reductase (ENR), a critical enzyme in type II fatty acid biosynthesis, is a promising target for drug discovery against hepatocyte-stage Plasmodium falciparum. In order to identify PfENR-specific inhibitors, we docked 70 FDA-approved, bioactive, and/or natural product small molecules known to inhibit the growth of whole-cell blood-stage P. falciparum into several PfENR crystallographic structures. Subsequent in vitro activity assays identified a noncompetitive low-micromolar PfENR inhibitor, celastrol, from this set of compounds.
Authors:
Lorillee Tallorin; Jacob D Durrant; Quynh G Nguyen; J Andrew McCammon; Michael D Burkart
Related Documents :
10350609 - S' subsite mapping of serine proteases based on fluorescence resonance energy transfer.
1908859 - Inhibition of subtilisin bpn' by reaction site p1 mutants of streptomyces subtilisin in...
25267679 - Small-molecule inhibitors of the pseudaminic acid biosynthetic pathway: targeting motil...
25284249 - Celastrol inhibits plasmodium falciparum enoyl-acyl carrier protein reductase.
9261179 - Characterization of the precursor of prostate-specific antigen. activation by trypsin a...
2052489 - Vasoactive intestinal polypeptide precursors have highly potent bronchodilatory activity.
72069 - Complexing rauscher leukemia virus reverse transcriptase with human plasma ribonuclease...
21541749 - Combining molecular dynamics and docking simulations of the cytidine deaminase from myc...
10447099 - Synthesis of 153n-6 analogues and structure-function analysis at murine melanocortin-1 ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-15
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  -     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-6     Completed Date:  -     Revised Date:  2014-10-7    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ?-Functionalization of Carboxylic Anhydrides with ?-Alkyl Substituents through Carbene Organocatalys...
Next Document:  Tryptophan-based fluorophores for studying protein conformational changes.