| Cefuroxime-induced coronary artery spasm manifesting as Kounis syndrome. | |
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MedLine Citation:
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PMID: 15999477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergic angina and allergic myocardial infarction (Kounis syndrome) occurring during the course of a drug-induced allergic reaction in the absence of angiographically stenosed coronary arteries, is rare in clinical practice. This paper reports the case of a 70-year-old woman with no significant risk factors for coronary artery disease who developed coronary artery spasm after intravenous injection of cefuroxime. A subsequent coronary angiogram revealed normal coronary arteries (type I variant of the syndrome). The allergic reaction following cefuroxime administration seems to have triggered the development of coronary artery spasm. Susceptible individuals expressing an amplified mast cell degranulation effect may be more vulnerable to coronary artery spasm. The clinical implications of this syndrome are also discussed. |
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Authors:
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Andreas Mazarakis; Constantinos M Koutsojannis; Nicholas G Kounis; Dimitrios Alexopoulos |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta cardiologica Volume: 60 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-07 Completed Date: 2005-09-01 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 341-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Patras, Medical School, Patras, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / chemically induced*, immunology, physiopathology Anti-Bacterial Agents / administration & dosage, adverse effects* Cefuroxime / administration & dosage, adverse effects* Coronary Angiography Coronary Vasospasm / chemically induced*, immunology, physiopathology Electrocardiography Female Humans Injections, Intravenous Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 55268-75-2/Cefuroxime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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