Document Detail


Ceftriaxone as a single agent in empirical therapy of unexplained fever in granulocytopenic children with solid tumors.
MedLine Citation:
PMID:  9210007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The optimal management of fever in granulocytopenic cancer patients remains controversial. Antibiotic monotherapy is increasingly an option for the initial empiric treatment of febrile granulocytopenic patients with solid tumors. Available data show that response to empiric therapy is often more related to disease classification (solid tumors vs. acute leukemia) than to the regimen used. In this study we based empiric monotherapy on the underlying disease (solid tumors) in treating 33 episodes of fever in 26 granulocytopenic children with cancer. We investigated the potential effectiveness of single daily doses of ceftriaxone administered empirically in febrile granulocytopenic children with solid tumors. Fever was treated successfully with ceftriaxone monotherapy in 91% (30/33) of febrile episodes. None of the patients died as a result of primary infection. These results suggest that empirical monotherapy with once-daily ceftriaxone is safe and effective. In addition, when compared with other extended-spectrum cephalosporins such as ceftazidime, once-daily administration of ceftriaxone reduces cost and patient inconvenience, allowing convenient parenteral therapy even on an outpatient basis.
Authors:
S Bartolozzi; A Clerico; E Properzi; A Minori; M A Castello
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  9     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-21     Completed Date:  1997-08-21     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  227-31     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University La Sapienza, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Agranulocytosis / complications*
Ceftriaxone / therapeutic use*
Cephalosporins / therapeutic use*
Child
Child, Preschool
Female
Fever of Unknown Origin / drug therapy*
Humans
Infant
Male
Neoplasms / complications*
Prospective Studies
Risk Factors
Chemical
Reg. No./Substance:
0/Cephalosporins; 73384-59-5/Ceftriaxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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