| Ceftriaxone (Rocephin) in abdominal trauma. | |
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MedLine Citation:
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PMID: 1942169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study was undertaken to evaluate the use of ceftriaxone in patients with abdominal trauma admitted to our hospital over a period of 6 months. Because of the large trauma load and an unacceptable waiting period before surgery combined with the fact that many patients on 6-hourly antibiotic regimes often did not receive their second and third doses, it was decided to use ceftriaxone because of its long half-life with maintenance of fluid and tissue concentrations for 24-48 hours. Because ceftriaxone is not reliably effective against anaerobic organisms such as Bacteroides fragilis, it was decided to add metronidazole as a combined initial dose. Two hundred ninety patients were entered in this trial, of which there were 259 stab wounds (89.3%), 20 missile injuries (6.9%), and 11 blunt injuries (3.8%). It was found that the mean delay between injury and initial dosage of ceftriaxone was 9.1 hours, with a range of 1-126 hours, and the mean delay between antibiotic therapy and operation 6.3 hours, with a range of 0-39 hours. The organs most frequently injured were the small bowel, the large bowel, the stomach, and the liver. Wound infection developed in only 4 patients (1.4%); intra-abdominal sepsis did not occur; and 35 patients (12%) developed respiratory infections. There were no deaths. We conclude that ceftriaxone, because of its 24-hour dosage was not only convenient but also adequate to prevent intra-abdominal sepsis and there was no difference in cost between this product and our previous protocol of 6-hourly antibiotic regime. |
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Authors:
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L C van Rensburg; B Warren; V Warren; R Müller |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 31 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-23 Completed Date: 1991-12-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1490-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Faculty of Medicine, University of Stellenbosch, Republic of South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Injuries
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microbiology*,
surgery Adolescent Adult Aged Ceftriaxone / therapeutic use* Humans Male Middle Aged Premedication* Preoperative Care Prospective Studies Time Factors Wound Infection / prevention & control* Wounds, Penetrating / microbiology, surgery |
| Chemical | |
Reg. No./Substance:
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73384-59-5/Ceftriaxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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