Document Detail

Ceftriaxone (Rocephin) in abdominal trauma.
MedLine Citation:
PMID:  1942169     Owner:  NLM     Status:  MEDLINE    
A prospective study was undertaken to evaluate the use of ceftriaxone in patients with abdominal trauma admitted to our hospital over a period of 6 months. Because of the large trauma load and an unacceptable waiting period before surgery combined with the fact that many patients on 6-hourly antibiotic regimes often did not receive their second and third doses, it was decided to use ceftriaxone because of its long half-life with maintenance of fluid and tissue concentrations for 24-48 hours. Because ceftriaxone is not reliably effective against anaerobic organisms such as Bacteroides fragilis, it was decided to add metronidazole as a combined initial dose. Two hundred ninety patients were entered in this trial, of which there were 259 stab wounds (89.3%), 20 missile injuries (6.9%), and 11 blunt injuries (3.8%). It was found that the mean delay between injury and initial dosage of ceftriaxone was 9.1 hours, with a range of 1-126 hours, and the mean delay between antibiotic therapy and operation 6.3 hours, with a range of 0-39 hours. The organs most frequently injured were the small bowel, the large bowel, the stomach, and the liver. Wound infection developed in only 4 patients (1.4%); intra-abdominal sepsis did not occur; and 35 patients (12%) developed respiratory infections. There were no deaths. We conclude that ceftriaxone, because of its 24-hour dosage was not only convenient but also adequate to prevent intra-abdominal sepsis and there was no difference in cost between this product and our previous protocol of 6-hourly antibiotic regime.
L C van Rensburg; B Warren; V Warren; R Müller
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  31     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-23     Completed Date:  1991-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1490-4     Citation Subset:  AIM; IM    
Department of Surgery, Faculty of Medicine, University of Stellenbosch, Republic of South Africa.
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MeSH Terms
Abdominal Injuries / microbiology*,  surgery
Ceftriaxone / therapeutic use*
Middle Aged
Preoperative Care
Prospective Studies
Time Factors
Wound Infection / prevention & control*
Wounds, Penetrating / microbiology,  surgery
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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