Document Detail

Cefotetan versus conventional triple antibiotic prophylaxis in elective colorectal cancer surgery.
MedLine Citation:
PMID:  20191043     Owner:  NLM     Status:  MEDLINE    
This study examined infectious outcomes in elective colorectal cancer surgery between cefotetan alone or conventional triple antibiotics. From January to December 2007, 461 consecutive primary colorectal cancer patients underwent elective surgery. Group A contained 225 patients who received conventional triple antibiotics (cephalosporin, aminoglycoside and metronidazole) for prophylaxis, and group B contained 236 patients who received cefotetan alone for prophylaxis. Treatment failure was defined as the presence of postoperative infection including surgical-site infection (SSI), anastomotic leakage, and pneumonia or urinary tract infection. The two groups were similar in terms of demographics, American Society of Anesthesiologists (ASA) score, tumour location, stage, surgical approach (conventional open vs. laparoscopy-assisted), and type of operation. The treatment failure rates were 3.1% in Group A and 3.4% in Group B (absolute difference, -0.3%; 95% confidence interval [CI], 0.39 to 3.07, P=0.866), with SSI being the most common reason for failure in both groups (2.7% in Group A and 3.0% in Group B [absolute difference, -0.3%; 95% CI, 0.37 to 3.37, P=0.846]). Cefotetan alone is as effective as triple antibiotics for prophylaxis in primary colorectal cancer patients undergoing elective surgery.
Woon Kyung Jeong; Ji Won Park; Seok-Byung Lim; Hyo Seong Choi; Seung-Yong Jeong
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Publication Detail:
Type:  Journal Article     Date:  2010-02-17
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-18     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM    
Department of Colon and Rectal Surgery, Sunlin Hospital, Pohang, Korea.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis*
Cefotetan / therapeutic use*
Colorectal Neoplasms / surgery*
Drug Therapy, Combination
Middle Aged
Postoperative Complications / prevention & control*
Surgical Wound Infection / prevention & control*
Treatment Failure
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 69712-56-7/Cefotetan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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